Product introduction
A novel topical small molecule called PP405 was created for cutting-edge research on hair follicle stem cells (HFSCs). PP405, which targets the Mitochondrial Pyruvate Carrier (MPC), was created based on groundbreaking research at UCLA. PP405 functions as a potent molecular switch to "wake up" latent hair follicles by modulating cellular metabolism toward lactate generation through the inhibition of MPC.
Chemical Target: Mitochondrial Pyruvate Carrier (MPC)
Purity: ≥≥ 99.0% (Verified by HPLC & 1H-NMR)
Form: High-stability crystalline powder
Grade: Laboratory Research;
COA & Quality
Every batch of PP405 is guaranteed to adhere to strict pharmaceutical-grade research requirements by TIANJIN YINAO. Included in our Certificate of Analysis (COA) are:
HPLC Analysis: Guaranteed purity ≥≥ 99.0%.
1H-NMR/MS: Confirmation of molecular structure and exact mass.
Impurity Profile: Control of heavy metals and extremely low residual solvents.
Stability Data: Verified shelf-life under optimized storage conditions.
Competitive: PP405 vs. Traditional
In contrast to standard therapies, PP405 provides a regenerative, non-hormonal approach:
| Feature | Minoxidil (Classic) | PP405 (Regenerative) |
|---|---|---|
| Mechanism | Vasodilation (Blood flow) | MPC Inhibition (Metabolic) |
| Target | Blood vessels | Follicle Stem Cells (HFSC) |
| Pathway | Indirect stimulation | Local metabolic "Switch" |
| Systemic Risk | Cardiovascular focus | Minimal (Localized action) |
Metabolic Switch Flowchart
| Test Item (检测项目) | Specification (标准要求) | Results (检测结果) | Method (检测方法) |
|---|---|---|---|
| Appearance | White to light yellow crystalline powder | Conforms | Visual Inspection |
| Identification (1H-NMR) | Must conform to the structure | Conforms | Bruker 400MHz |
| Identification (LC-MS) | Exact Mass: 452.06 ± 0.5 | 452.08 | Agilent LC-MS |
| Purity (HPLC) | ≥≥ 99.0% | 99.51% | HPLC-UV (254nm) |
| Loss on Drying | ≤≤ 0.5% | 0.18% | 105°C, 3 hours |
| Residue on Ignition | ≤≤ 0.1% | 0.03% | USP <281> |
| Heavy Metals | ≤≤ 10 ppm | < 3 ppm | ICP-MS |
| Specific Impurity | Single ≤≤ 0.5% | 0.15% | HPLC |
- Analytical Fidelity: A single, crisp peak in the HPLC chromatogram shows that the synthesis precursors and byproducts have been successfully removed.
- MPC Inhibition Potency: The validated structure is compatible with the high-affinity MPC inhibitor profile (JXL series), which is tailored for studies on the metabolic reprogramming of hair follicle stem cells (HFSCs).
- Stability: Compared to inhibitors from previous generations, the 3,5-bis(trifluoromethyl)benzyl moiety offers improved chemical stability.
Function& Research Applications
- The potential of metabolic reprogramming to change glucose metabolism in stem cells toward the glycolytic route is being studied.
- HFSC Activation: Research on modifying mitochondrial respiration to re-trigger the hair growth cycle (Anagen phase).
- Topical Formulation Studies: Used in dermatological research to create localized, non-systemic delivery models.
OEM&ODM
Certifications
Higher standards, more reassuring protection
Company
Tianjin Yinao Technology Co.,Ltd. was established in 2017, located in the fashion city of China - Tianjin. There is a comprehensive company integrating a full range of production, sales and service. Focus on OEM processing, especially any kinds of capsules, bottles and so on. Mainly exporting medicine and nutritional supplements, pharmaceutical products and bodybuilding series to support life science research and development, with approximately one hundred complex manufacturing services projects.
We are professional supply for loss weight, there are many kinds of peptides, such as semaglutide, tireptide.
We are committed to ensuring human health, providing consistent quality and sustainable growth.
Delivery & Shipping &Package
International Express-- Fedex/DHL/UPS, air shipping and sea shipping, double-clearance custom.
|
Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
|
Port |
China main port |
Why Choose Us?
Q: Can a get a free sample ?
A: We can provide you with free samples, you only need to pay for the shipping cost.
Q: How can I trust you ?
A: Our owner has over 20 years of experience in the chemical raw materials field as well as our staffs. It is because of the trust of our customers and partners that we have been able to exist and develop for so many years. Our ever-lasting vision is to 'Obtain a wide range of customer resources through high-quality procurement and the best service, and establish a sustainable and stable customer relationship'!
Q:How do you guarantee the quality of your products?
A: All of our products comply with national testing standards and international standards. If you need, we can provide you with certificates.
Q:Can you use customer-specific labeling and packing?
A: Of course, you can provide us with the specified labeling and packaging and we will be happy to follow up with you.assist you. If there is anything else you need, please feel free to communicate with us!
Q:How about delivery time and method?
A: We usually ship within 3-5 working days after payments.
We can make ships by sea, air, or express. Also can make door-to-door shipping
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