Products Description

Retatrutide is a multi-target incretin receptor agonist designed to support weight management. It works by simultaneously activating receptors for GLP-1, GIP, and glucagon-key regulators of energy metabolism and appetite.

As a fatty-acylated single-chain peptide, retatrutide binds to and activates three receptors: GCGR (glucagon receptor), GIPR (glucose-dependent insulinotropic polypeptide receptor), and GLP-1R (glucagon-like peptide-1 receptor). Its structurally engineered fatty acid side chain extends the molecule's duration in the bloodstream, allowing for once-weekly dosing.

A synthetic triple agonist peptide that targets the GLP-1, GRP, and glucagon receptors is called retatrutide (LY3437943). Its complicated structure-a 39-amino acid sequence with a fatty acid side chain-means that high-resolution methods (HRMS) are needed for its Mass Spectrometry (MS) investigation.

For laboratory research use only.

COA

ProductName	Retatrutide		CASNo.CAS		CAS:2381089-83-2
MolecularFotmula	C₂2₁H₃₁₂Na₆O₆8		MolecularWeight		4731.42
Structuralformula
BatchNo.	SY20250915-030		Quantity		2444.56g
Mfgt.Date	2025/12/16		Retest Date		2027/12/15
Tests		Acceptance Criteria			Results
Appearance		Whiteoroff-whitepowder			White powder
Solubility		Canbedissolvedto5mg/mlinpurewater			Conforms
MolecularIonMass		4731.42±1			Conforms
pH		7.0~9.0(C=5mg/ml)			7.46
WaterContent(K.F)		NMT8.0%			3.40%
Purity(HPLC)		NLT98.0%			99.40%
Relatedsubstances(HPLC)		ThelargestindividualimpuritytestNMT1.0%			0.38%
		ThetotalimpuritiestestNMT2.0%			0.60%
Residualsolvent(GC)		Methylenechloride		NMT600ppm	N.D
		Acetonitrile		NMT410ppm	342ppm
		Methanol		NMT3000ppm	N.D
		NN-Dimethylformamide		NMT880ppm	N.D
		Isopropylether		NMT5000ppm	N.D
Acidgroupions(HPLC)		TFA		NMT0.1%	N.D
		PO4³		NMT0.1%	N.D
		Cl		NMT0.1%	N.D
		HAC		NMT0.1%	N.D
BacterialEndotoxins		NMT10EU/mg			Conforms
Microbial Limits		TAMC		NMT1000cfu/g	Confoms
		TYMC		NMT100cfu/g	Conforms

Microbial Limits	Escherichia Coil presence	Negative		Conforms
	Salmonella	Negative		Conforms
	P.Aeruginosa	Negative		Conforms
	S.Aureus	Negative		Confoms
Sodium ion	NMT 5.0%		1.3%
Peptide Content(Mass Balance)	NLT 80.0%		94.8%
Conclusion: Conformed with the product standards.
Storage Conditions:Keep in right concainer,protect fom light,store at a remperature of-20±5℃.
Detection: Yang Wang Sanction: Yangling Huang

Function&Uses

1.Promote fat breakdown:

Promote the breakdown of stored fat through the activation of glucagon receptors, increasing energy expenditure.

2.Suppress appetite:

Delay gastric emptying, reduce food intake, and decrease central hunger.

3. Regulate metabolism:

Improve insulin sensitivity and reduce the risk of blood sugar fluctuations.

Application

In a 48-week study, Retatrutide achieved an average weight loss of 24.2%, significantly outperforming traditional GLP-1 receptor agonists. It is currently primarily used for obesity treatment.