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Tianjin Yinao Technology Co.,Ltd. was established in 2017, located in the fashion city of China - Tianjin. There is a comprehensive company integrating a full range of production, sales and service. Mainly exporting medicine and nutritional supplements, pharmaceutical products and bodybuilding series to support life science research and development, with approximately one hundred complex manufacturing services projects.
Why Choose Us
Comprehensive Production and Service Capabilities
Since its establishment, Tianjin Yinao Technology Co., Ltd. has developed a comprehensive business model covering production, sales, and service, capable of meeting customer needs at multiple stages and providing one-stop solutions.
Strong OEM Processing Capabilities
The company specializes in OEM processing, particularly in capsules and bottled products, enabling customized production according to customer requirements and providing high-quality, rapid-response services.
Production Market
Tianjin Yinao's products are widely exported to multiple international markets, including the Americas, Europe, Southeast Asia, and Australia, possessing a deep global business network that allows for rapid adaptation to diverse market demands.
Life Science R&D Support
The company primarily manufactures pharmaceuticals, nutritional supplements, and fitness products, dedicated to supporting life science research and development. It offers approximately one hundred complex manufacturing service projects, providing high-quality products for global scientific research.
Ketone esters are supplements that are orally consumed to quickly raise blood ketone levels, putting the body into a state of ketosis where it burns fat for fuel without a ketogenic diet. They were developed to improve performance and focus, and potential benefits include enhanced cognitive function, reduced inflammation, and improved endurance and recovery.
Agomelatine is an antidepressant used to treat depression. The brain is usually good at making sure we have enough of the chemicals we need to function properly. But depression can affect our brain chemicals, including noradrenaline, dopamine and serotonin.
Curb Carb Cravings
If you’re on a low-carb diet but you find yourself craving carbs, take 1 or 2 teaspoons of ketone esters. Ketone Esters supply the brain directly with the fuel that it needs.
Increase Endurance
You’re probably wondering how these supplements would be able to improve physical performance. Using ketone esters can increase the use of fat during exercise and preserve glycogen reserves until later in the workout.
Improve Muscle Recovery
Ketone esters can help with muscle recovery after exercising. They increase the rate of energy store replenishment in the body and support the process of rebuilding muscles.
Enhance Cognitive Function
Studies have shown that with the use of these supplements, cognitive function may improve, especially after exercise. Ketones are known for being ideal fuel for the brain in general and specifically when food sources, notably carbs, are limited.
Improve Medical Conditions
Some research demonstrates that using ketone esters can actually suppress the expression of an inflammatory pathway that is linked to several diseases, including arthritis. They can also possibly aid in reducing seizure activity in patients with epilepsy, reversing early neuronal hyperactivity in Alzheimers and dementia patients, and reducing anxiety.
Advantages of Agomelatine
Restores sleep and circadian rhythms
Agomelatine helps normalize disrupted sleep patterns and improves sleep efficiency, quality, and the overall sleep-wake cycle.
Unique mechanism of action
It works on melatonergic (MT1 and MT2) and serotonin (5-HT2C) receptors, which differs from many other antidepressants.
Favorable safety profile for certain patients
Its lack of serotonergic effects makes it a potential option for patients who are at risk of serotonin syndrome, bleeding, or hyponatremia.
Effective for anxiety and depression
Studies show it is effective in reducing both major depressive and anxiety symptoms.
Product Description
|
Product name |
Agomelatine |
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Other name |
N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide |
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CAS No. |
138112-76-2 |
|
MF |
C15H17NO2 |
|
MW |
243.3082 |
|
Purity |
99.0% |
|
Appearance |
White to off-white crystalline powder |
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Package |
1kg/bag;25kg/drum |
|
Storage |
Store in a sealed, dry place at room temperature, away from direct sunlight. |
Preparation method of Ketone Ester
Under stirring at room, add 65g dimethyl malonate successively in the 500ml there-necked flask, 0.5g sodium iodide and 200ml DMF stir evenly.Add wherein the 25g sodium methylate, stirring at room 30 minutes, and then drip wherein the 45g chloropropane, drip off in 30 minutes.Then stirring at room 1 hour is warming up to 40 ℃ and continues reaction 5 hours.Stopped reaction removes DMF under reduced pressure, adds 200ml distilled water in residuum, obtained aqueous solution ethyl acetate extraction twice, each consumption 300ml.Combining extraction liquid is successively used 200ml distilled water and the water washing of 200ml saturated common salt, anhydrous sodium sulfate drying, and decompression is spin-dried for solvent, and 130 ℃/30mmHg cut is collected in the residuum underpressure distillation, gets 78g light yellow transparent liquid product, productive rate 91%.
Under stirring at room, add the 600ml dehydrated alcohol in the 1L four-hole boiling flask, carefully add the 32g sodium methylate, stirring at room dissolving 20 minutes.Disposable 127g propylmalonic acid dimethyl ester and the 142g Isopentyl nitrite of adding, finish wherein, was warming up to back flow reaction 2 hours.Install water distilling apparatus additional, the solvent underpressure distillation to quick-drying, is added 300ml distilled water in residuum, with ethyl acetate extraction twice, each consumption 400ml.Merge organic phase, successively use 200ml distilled water and the water washing of 200ml saturated common salt, anhydrous magnesium sulfate drying is evaporated to driedly, and 105 ℃/2mmHg cut is collected in the underpressure distillation of residuum oil pump, gets 90g white low melting point solid, yield 85%.
Under stirring at room, add successively 73g alpha-ketoxime methyl valerate in the 1L four-hole boiling flask, 300ml methyl alcohol, 300ml acetone and 100ml 20% sulfuric acid, stirring at room 3 hours, then the temperature rising reflux reaction is 2 hours.Reaction solution is down to room temperature naturally, then is transferred in the 2L separating funnel, uses dichloromethane extraction three times, each consumption 500ml.Merge organic phase, successively use 400ml distilled water and the water washing of 400ml saturated common salt, anhydrous magnesium sulfate drying, concentrating under reduced pressure, 62 ℃/12mmHg cut is collected in the residuum underpressure distillation, gets 52g colourless liquid product, yield 80.6%, 1H NMR .
Application of Ketone Ester
Endurance athletics
Ketone esters can improve endurance exercise performance by providing an alternative fuel source to glucose.
Glycogen sparing
They may help spare glycogen stores during exercise, allowing for a greater capacity to perform for a longer duration.
Post-exercise recovery
Ketone esters can enhance markers of muscle protein synthesis during recovery from exercise, though they do not appear to increase muscle glycogen resynthesis.
Delivery & Shipping &Package
|
Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
|
Port |
China main port |
FAQ
As one of the leading api pharmaceutical enterprises in China, we warmly welcome you to buy bulk high-grade api pharmaceutical in stock here from our factory. All customized products are with high quality and low price. For more information, contact us now.
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