Products Description

SLU-PP-332 offers researchers a potent ERR agonist compound with demonstrated efficacy in metabolic pathway modulation. This high-quality material supports scientific investigations into exercise mimetics and metabolic disease interventions, providing reliable consistency for research reproducibility.

A strong, unique, and effective pan-agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ) is SLU-PP-332. It is now the most advanced tool for researching the molecular processes of energy expenditure and mitochondrial biogenesis because it is a non-hormonal nuclear receptor modulator.

Parameter	Specification
Product Name	SLU-PP-332
Chemical Name	(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
CAS NO.	303760-60-3
Molecular Formula (MF)	C18H14N2O2
Molecular Weight (MW)	290.32 g/mol
Purity (HPLC)	≥98% (Standard) / ≥99% (High Grade)
Physical Appearance	White to Off-white solid/powder
Solubility	Soluble in DMSO (≥50 mg/mL); Insoluble in H2O
Storage	Powder: −20°C for 3 years; In solvent: −80°C for 6 months

Mechanism of Action: The ERRα/β/γ Triple Agonism

In contrast to conventional metabolic modifiers, SLU-PP-332 specifically targets the Estrogen-Related Receptors, the "master switches" of energy metabolism in oxidative tissues (heart, skeletal muscle, etc.).

The expression of genes related to fatty acid oxidation and mitochondrial biogenesis is triggered by ERRα (Alpha) activation. In essence, it "teaches" the cell to use fat as its main energy source.
ERRβ (Beta) & ERRγ (Gamma) Synergy: These isoforms cooperate with ERRα to improve glucose absorption and raise type I (slow-twitch) muscle fiber density-the same physiological adaption observed in top endurance athletes.
The "Exercise Mimetic" Effect: SLU-PP-332 simulates the metabolic advantages of intense aerobic exercise at the cellular level even in the absence of physical activity by inducing a state of Oxidative Phosphorylation (OXPHOS) by activating all three ERR isoforms.

Functional Properties

Mitochondrial Biogenesis: It increases skeletal muscle's ability to produce energy by promoting the synthesis of new mitochondria.
Fatty Acid Oxidation: It helps reduce fat mass by changing the body's tendency for burning fat instead of glucose.
Endurance Enhancement: SLU-PP-332 has been demonstrated to improve running time by 45% and running distance by up to 70% in animal studies.
Metabolic Syndrome Alleviation: It is a potential treatment for Type 2 diabetes and obesity since it reduces plasma triglycerides and increases insulin sensitivity.

Applications in Metabolic Research

Mitochondrial Dysfunction: Research on cellular energy failure and age-related metabolic decline.
Skeletal Muscle Remodeling: Studies on fiber-type switching, endurance improvement, and muscle atrophy.
Metabolic Syndrome and Obesity: Examining non-insulin-dependent mechanisms for lipid metabolism and glucose control.
Cardiovascular Health: Examining how ERRs contribute to heart energy homeostasis.

Comparation

Feature	SLU-PP-332	BAM-15
Drug Class	Pan-ERR Agonist (Estrogen-Related Receptor)	Mitochondrial Uncoupler (Selective)
CAS NO.	303760-60-3	210302-17-3
Core Mechanism	Increases mitochondrial density by activating ERR α/β/γ, which mimics exercise signals.	Energy "Leakage": When the proton gradient is broken, energy is released as heat rather than ATP.
Primary Goal	Endurance & Muscle Quality Enhancement	Aggressive Fat Loss & Metabolic Rate Boost
Mitochondrial Impact	Biogenesis: Increases the quantity of factories that produce mitochondria.	Efficiency Reduction: Makes the mitochondria that are already there work harder.
Fat Loss Logic	Changes fuel choice and increases the oxidation of fatty acids.	Decreases metabolic efficiency, requiring the organism to use more energy in order to survive.
Endurance Performance	Significant Boost (Approx. 70% increase in running distance).	Indirect; emphasizes consumption over aerobic capacity.
Organ Protection	Possibility of anti-fibrosis and cardioprotection.	Non-Alcoholic Fatty Liver Disease (NAFLD) has significantly improved.
Safety Profile	Mimics the pathways of natural exercise and is quite mild.	Extremely safe; no risk of hyperthermia when compared to older uncouplers (such as DNP).
Best For	Lifespan, exercise mimetics, and avoiding muscular atrophy.	Rapid fat loss, treating obesity, diabetes research.

Institutional Support: Small Batch Availability

Small Batch Flexibility: We provide specific amounts (such as 500 mg, 1 g, and 5 g) designed for in-vitro tests and pilot studies, removing the need for a significant financial outlay.
Certified Purity: A Batch-Specific Certificate of Analysis (COA) with HPLC and mass spectrometry data is included with each institutional batch.
Global Research Logistics: Ensuring the molecular stability of the pan-agonist from our lab to your bench through temperature-controlled shipment and complete traceability.