Name: China 5-Amino-1-methylquinolinium Iodide Factory - Bulk 5-Amino-1-methylquinolinium Iodide - Yinao Technology
Brand: Yinao
SKU: 283368122

Products Description

5-Amino-1-methylquinolinium iodide (NNMTi) is an organic compound with the chemical formula C₁₀H₁₁N₂I and a molecular weight of 286.11. Its core structure is a quinoline ring with amino and methyl substituents, existing in the form of an iodide. NNMTi is a specific inhibitor of nicotinamide N-methyltransferase (NNMT) with an IC₅₀ value of 1.2 μM.

5-Amino-1-methylquinolinium iodide (abbreviated as 5-Amino-1MQ iodide) is a highly selective, substrate-competitive small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) (IC₅₀ ≈ 1.2 μM), serving as a core tool compound in current research on metabolism, aging, muscle regeneration, and oncology.

Test Item	Specification	Typical Result	Test Method
Assay	≥98.5%	99.23%	HPLC
Appearance	Orange-red to reddish-brown powder, free-flowing	Complies	Organoleptic Examination
Solubility	DMSO: ≥2 mg/mL, clear solution	Complies	Visual Solubility Test
Loss on Drying	≤1.5%	0.87%	EP 2.2.32
Residue on Ignition	≤0.3%	0.19%	EP 2.4.16
Single Impurity	≤0.5%	0.24%	HPLC
Total Impurities	≤1.0%	0.61%	HPLC
Iodide Content	44.0%–45.0%	44.58%	Potentiometric Titration
Total Heavy Metals	≤10 ppm	<7 ppm	ICP-MS
Pb	≤2 ppm	<1 ppm	ICP-MS
As	≤0.5 ppm	<0.3 ppm	ICP-MS
Cd	≤1 ppm	<0.5 ppm	ICP-MS
Hg	≤0.1 ppm	<0.05 ppm	ICP-MS
Total Aerobic Microbial Count	≤100 CFU/g	38 CFU/g	USP <61>
Yeast & Mold	≤10 CFU/g	2 CFU/g	USP <61>
E. coli / Salmonella	Negative	Negative	USP <62>
Endotoxin	≤0.5 EU/mg	<0.3 EU/mg	LAL Test (USP <85>)
Melting Point	212–215°C	213.5°C	DSC / Capillary Method
Particle Size	≥98% through 80 mesh	Complies	EP 2.9.12
Storage Condition	Sealed, protected from light at -20°C	Complies	Stability Test (ICH Q1A)
Shelf Life	24 Months	Complies	Accelerated & Long-term Stability

Core Mechanism: Mitochondrial Biogenesis

5-Amino-1MQ is a strong NNMT (nicotinamide N-methyltransferase) small-molecule inhibitor. It stops methyl donor depletion by inhibiting NNMT action, which raises intracellular NAD+ levels considerably.
The "master regulator" of mitochondrial biogenesis, PGC-1α (Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha), is activated as a result of this increase in NAD+.
The outcome of this metabolic cascade is:

Encouraging the production of new, functional mitochondria is known as mitochondrial biogenesis.
Enhanced Lipid Metabolism: Increasing the rate at which fatty acids are broken down ($\beta$-oxidation).
Increasing the basal metabolic rate and the total amount of energy used by cells is known as increased energy expenditure

HNMR & LCMS (Analytical Data)

1H NMR (Structure Verification)	LCMS (Purity Verification)

Conclusion: The absence of impurity peaks guarantees that the molecular structure is 100% accurate, and the distinctive peak positions (7.0–9.5 ppm, aromatic area) precisely match the standard structure.	Conclusion：The base peak in the mass spectrum at m/z 159 (cation) is noticeable, the primary peak's retention time is clear, and the purity is found to be more than 99%.

Application

Its primary application is in the Medical grade sector.

Metabolic Disease Research.
Aging & Longevity Science.
Oncology Biology.
Muscle & Sports Science: Muscle regeneration, exercise recovery, endurance enhancement, muscular atrophy research
Neuroscience.
Drug Discovery & Development.

Ordering Process & Support

Our streamlined ordering process begins with you sending the product CAS and details. We then confirm requirements and prepare a sample. Once you confirm the sample, we issue an invoice for payment and begin bulk production. We provide samples from stock within 3 working days. Payment methods include TT, Pingpong, Alibaba, or WestUnion. We ship via DHL/Fedex/Air/Sea. Choose us for our 10-year API/peptide specialization, advanced quality systems, and 24-hour service.

For reagent-grade products, TIANJIN YINAO provides specific support:
Small Packaging & Express Shipping: We offer small-scale packaging alternatives, like 1g, 5g, and 10g quantities, that are frequently utilized in laboratories. Orders are shipped by FedEx, DHL, or SF Express within a day of being placed because there is enough inventory on hand.
Complete COA Included: A comprehensive Certificate of Analysis (COA) with data from NMR spectroscopy and HPLC purity analysis is included with every batch.

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