Products Description

Adipotide is a polypeptide drug mainly used in the research fields of obesity and metabolic diseases. It achieves weight loss effects by promoting the apoptosis of adipocytes. The peptidomimetic chemical adipotide, sometimes referred to as FTPP or by its peptide sequence CKGGRAKDCGG-D(KLAKLAK)2, is presently being studied for its capacity to target and decrease white adipose tissue (WAT).

Sequence: CKGGRAKDCGG - D(KLAKLAK)_2

Molecular composition:

Targeting Domain: CKGGRAKDC. This segment functions as a "homing device" that attaches itself to receptors on the surface of blood vessel cells that produce white fat, mainly Prohibitin.
D(KLAKLAK)_2 is the pro-apoptotic domain. This synthetic antimicrobial peptide derivative is intended to cause mitochondrial membrane disruption, which will lead to programmed cell death (apoptosis).
Solubility: Usually soluble in physiological saline or water.

Summary:

Items	Description
CAS Number	859216-15-2
Molecular Formula	C₁₁₁H₂₀₆N₃₆O₂₈S₂
Molecular Weight (MW)	~2557.2 g/mol
Mechanism of Action	Prohibitin targets the endothelium of white adipose tissue and causes apoptosis.
Biological Activity	Enhances insulin sensitivity and reduces fat quickly and selectively
Form	Powdered lyophilized
Purity	≥95% (HPLC)
Storage	Store at –20°C, light protected, aliquot after reconstitution
Drug Types	Peptide angiogenesis inhibitor; experimental anti-obesity
Additional Notes	For research only; not for human/veterinary drug use.

Our company specializes in API and peptide materials with a decade of experience. We offer Adipotide peptide with various specifications to meet diverse research needs. The product is available for immediate shipment as it is currently in stock.

We provide comprehensive customer support with 24-hour after-sales service. Our efficient talent management team ensures rapid response to customer needs. We maintain an advanced production management system that guarantees product quality and reliable supply chain capacity.

Mechanism of Action (MOA)

Adipotide functions by "cutting off the supply line" in contrast to conventional fat burners, which seek to increase metabolism within fat cells:
Selective Binding: The targeting domain recognizes and attaches itself to the blood vessel endothelial cells that supply white adipose tissue.
Apoptosis Induction: After binding, the pro-apoptotic peptide enters these vascular cells and damages the integrity of their mitochondria, resulting in cell death.
Adipose Atrophy: When the related fat cells are deprived of blood supply (oxygen and nutrients), they atrophy and are eventually reabsorbed by the body.
Metabolic Improvement: Increased insulin sensitivity frequently follows the subsequent decrease of fat mass.

Primary Applications & Research Areas

A. Research on Obesity
The main emphasis of research on adipotide is this. Adipotide has shown notable weight-loss results in studies using non-human primates (such rhesus monkeys):

Quick Weight Loss: Over a brief period of time, the subjects' overall body weight significantly decreased.
Waist Circumference Reduction: It reduces the percentage of body fat by focusing on visceral and subcutaneous abdominal fat.

B. Disorders of the Metabolism
Because Adipotide affects adipose tissue, scientists utilize it to investigate:

Type 2 Diabetes: Examining how this kind of quick weight loss enhances insulin resistance and glycemic management.
Lipid Regulation: Monitoring how fat loss affects serum cholesterol and triglyceride levels.

C. Research Concerning Oncology
Adipose tissue secretes substances that are conducive to the growth of several malignancies. Researchers are investigating if reducing body fat using Adipotide can indirectly slow the development of malignancies linked to obesity, like prostate or breast cancer.

Limitations & Side Effects

Adipotide confronts challenges in clinical translation, despite encouraging outcomes in animal models:

Nephrotoxicity: Research on primates showed that there was a chance of kidney injury (lesions), which were usually curable but needed careful observation.
Difficulties with Specificity: Despite being made for vessels that are unique to fat, there is always a chance of slight cross-reactivity with endothelial cells in other tissues.
Adipotide's current regulatory status is Research Use Only (RUO). The FDA and other regulatory agencies have not authorized it for clinical use in humans.

Ordering Process

Please send us product CAS and more details. We will confirm product requirements and prepare samples. Samples are shipped promptly until clients receive and confirm. For samples in stock, we ship within 3 working days. OEM samples require 5-8 working days. Once samples are confirmed, we send an invoice with shipment details for payment processing. Bulk production begins after payment confirmation.