Amoxicillin Powder for Poultry

Amoxicillin Powder is a pharmaceutical-grade active pharmaceutical ingredient supplied as a fine powder, used in veterinary pharmaceutical manufacturing and industrial formulation production.

Chemical Class: Aminopenicillin.

• Mechanism of Action: By preventing peptidoglycan from cross-linking, it compromises the structural integrity of bacterial cell walls. This results in the bacteria rupturing and dying during the phase of development and division (bactericidal activity).
• Antibacterial Spectrum: Effective against a number of Gram-negative bacteria, including E. coli, Pasteurella, and Salmonella, as well as the majority of Gram-positive bacteria, including Streptococcus and Staphylococcus.

  Certificate of analyze
  Product name	Amoxicillin
  CAS NO.	61336-70-7
  Molecular formula	C16H19N3O5S · 3H2O
  Appearance	White to off-white solid
  Assay	Typically 95.0%–102.0% (anhydrous basis) or 900g/mg.
  Identification (IR/LCMS)	Consistent with structure.
  Water Content (Karl Fischer)	11.5%–14.5% (consistent with trihydrate form)
  pH	3.5 – 5.5
  Residual Solvents	Complies with USP/EP standards.
  Storage	Typically -10°C to -25°C for long-term, or room temperature in a tightly closed container.

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In therapeutic settings, amoxicillin is used to treat a variety of infections brought on by susceptible bacteria:

• Respiratory infections include shipping fever (pasteurellosis) in cattle, infectious coryza in chickens, and pleuropneumonia in pigs.
• Salmonellosis and E. Coli diarrhea are examples of gastrointestinal infections.
• Endometritis, mastitis, and postpartum infections in cattle are examples of urogenital infections.
• Foot rot and wound infections are examples of skin and soft tissue infections.
• Systemic infections include septicemia and streptococcosis in pigs.
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Active Ingredient is used to list dosages. It is frequently used in veterinary medicine as either Amoxicillin Injection (IM/SC) or Amoxicillin Soluble Powder (for water/feed).

A. Poultry (Chickens, Turkeys)

Used for salpingitis, colibacillosis (E. coli), and pullorum disease.

• Drinking Water: 10 – 20 mg/kg body weight.

Practical Guide: Typically 0.5g – 1g of a 10% soluble powder per 1L of water for 3–5 days.

• Mixed Feed: 200 – 400 mg per kg of feed.

B. Swine

Dosages are listed using the active ingredient. In veterinary medicine, it is commonly administered as either Amoxicillin Soluble Powder (for water/feed) or Amoxicillin Injection (IM/SC).

• Water/Feed: 10 – 15 mg/kg body weight, twice daily for 3–5 days.
• Intramuscular (IM) Injection: 7 – 15 mg/kg body weight, once daily.

C. Cattle & Sheep

Used for pneumonia, hemorrhagic septicemia, and mastitis.

• Oral: 10 mg/kg body weight (only for pre-ruminant calves and lambs).

Note: Use injections instead of oral administration because it disturbs the rumen flora in mature ruminants.

• IM/SC Injection: once daily for three to five days at a dose of seven to ten mg/kg body weight.
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• Critical Precautions

   

A. Resistance & Drug Combinations

• Beta-lactamase Resistance: Penicillinase, an enzyme produced by many bacteria, deactivates amoxicillin. It is frequently used in conjunction with clavulanate potassium, which inhibits these enzymes and restores effectiveness, to combat this.
• Incompatibility: Because it is a bactericidal agent that targets the growth phase, it should not be administered with bacteriostatic medications like tetracyclines or erythromycin because they may counteract its effects.

B. Safety & Contraindications

• Ruminant Restriction: Because it might result in severe gastrointestinal dysbiosis, it should never be given orally to adult sheep or cattle.
• Species Sensitivity: Oral administration can cause possibly fatal colitis; use with extreme caution in horses and rabbits.
• Withdrawal Period*Meat: Depending on the particular product formulation, withdrawal periods typically range from 7 to 28 days.

                                       *Milk: Typically 48 – 96 hours. 

1. Submit the product CAS number and detailed specifications.
2. We review and confirm your requirements, then prepare the sample.
3. We ship the sample for your evaluation and approval.
4. Upon sample approval, we issue a proforma invoice with shipping details for payment processing.
5. Mass production begins after payment confirmation.
6. After order fulfillment, we coordinate with our logistics partners to arrange shipment.

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