Product introduction
Lithium ions and orotic acid, a naturally occurring pyrimidine derivative necessary for the synthesis of nucleic acids, combine to generate lithium orotate, a special lithium salt combination. It is soluble in water and polar solvents, usually appears as a white to off-white crystalline powder, and is stable when stored at room temperature, away from moisture, and out of direct sunlight. With a lower elemental lithium content (around 3.8% by weight) than conventional lithium carbonate, lithium orotate is known for its improved bioavailability and effective blood-brain barrier crossing. It has stringent purity requirements (≥98% for research and supplement use) and is offered in pharmaceutical, dietary supplement, and research-grade formulations.
| Certificate of analyse | |
| Product name | Lithium orotate |
| CAS NO. | 5266-20-6 |
| MF | C5H3LiN2O4 |
| Molar Mass | 162.03 g/mol |
| Appearance | Fine white powder |
| Form | White powder(often as monohydrate) |
| Standardization | 3.86% elemental lithium is usually the benchmark. |
| Dosage | Typically, each pill contains 4.8–5 mg of elemental lithium. |
| Solubility | Produces free lithium ions when dissolved. |
Core Functions
The Orotate carrier is the primary benefit of Lithium Orotate.
- Effective Penetration: Orotic acid is a molecule that has the ability to pass through cell membranes. As a "transport vehicle," it more efficiently transports lithium ions into the lysosomes and mitochondria of cells, particularly brain cells.
- High Activity at Low Doses: Lithium Orotate only needs micro-doses (often 5–20 mg of elemental lithium) to have neuromodulatory effects, in contrast to pharmaceutical-grade lithium carbonate, which typically requires doses of 600–1200 mg.
- Neuroprotection: Studies indicate that via increasing Brain-Derived Neurotrophic Factor (BDNF), lithium ions support neuronal survival and repair.
- Mood Stabilization: By controlling the activity of neurotransmitters like glutamate and dopamine, it aids in balancing mood fluctuations.
Application Fields
A. Dietary Supplements (Nutraceuticals)
This is currently the primary application.
- Mood regulation: Used to reduce emotional instability, impatience, and moderate anxiety.
- Stress management: Reduces sleeplessness and distractibility brought on by mental strain.
- Nootropics: Used to preserve long-term brain health as part of cognitive enhancement programs.
B. Neurodegenerative Disease Research
- Parkinson's and Alzheimer's disease: investigating the possibility of postponing cognitive decline.
- Anti-inflammatory Research: Investigating its potential to lessen persistent inflammation in the central nervous system.
C. Withdrawal Support
It supports emotional stability during alcohol or other substance withdrawal in certain naturopathic protocols.
Production & Synthesis Process
To guarantee high purity and structural stability, Lithium Orotate is usually manufactured in industrial and laboratory settings by chemical synthesis (chelation) as opposed to straightforward extraction.
- Preparation of Raw Materials: Orotic Acid (C5H4N2O4) and high-purity Lithium Carbonate (Li2CO3) or Lithium Hydroxide (LiOH) are made.
- Heating and Dissolution: Orotic acid is heated (usually to 80°C to 100°C) while suspended in deionized water.
- Neutralization/Chelation: Slowly add the lithium salt. Lithium orotate is created when the molecules of orotic acid react with the lithium ions.
- LiOH + C5H4N2O4 \rightarrow C5H3LiN2O4 + H2O is the simplified reaction.
- Filtration and Purification: The heated solution's unreacted contaminants are filtered out.
- Crystallization and Drying: A white crystalline powder is obtained by vacuum drying after crystallization is triggered by cooling or solvent precipitation.
- Milling and Packaging: Depending on the needs of the application, the powder is ground to precise particle sizes.
OEM&ODM
We offer a variety of dosage forms and neutral packaging, including mixed powders, granules, soft capsules, hard capsules, tablets, gummies, and more, to meet the diverse needs of our customers. Yinao is committed to providing customers with natural, safe, and organic plant extracts.
Certifications
The company consistently adheres to its corporate mission of creating a healthy life, strictly controls product quality, and holds certifications including ISO9001, Halal, and Kosher. It continuously innovates and develops, earning the high-tech enterprise certificate for several consecutive years.
Delivery & Shipping &Package
International Express-- Fedex/DHL/UPS, air shipping and sea shipping, double-clearance custom.
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Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
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Port |
China main port |
Why Choose Us?
1. More Than 15 Years Botanical Extract Supplier, and around 2000 kinds of products!
2. Focused on the development of plant active ingredients for more than 15 years and has a number of national invention patents.
3. International certification system: ISO9001, ISO22000, IP (non GMO), Jewish, halal, organic and other certification.
4. Professional and experienced r&d team: professors from famous universities and experts with decades of working experience in this industry.
5. Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
FAQ
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