Product introduction
LOXO-435, also known as LY3866288 or Vepugratinib, is a novel, highly selective small-molecule inhibitor targeting Fibroblast Growth Factor Receptor 3 (FGFR3). Designed to retain inhibitory activity against FGFR3 gatekeeper resistance mutations, LOXO-435 represents a valuable research compound for investigating FGFR3-driven tumor biology and emerging mechanisms of targeted therapy resistance.
With potential applications in FGFR3-altered advanced solid tumor research, particularly urothelial cancer studies, LOXO-435 provides researchers with an important tool for exploring next-generation precision oncology strategies.
Technical Specifications
| Specification | Details |
| Product Name | LOXO-435/LY3866288 / Vepugratinib |
| CAS Number | 2833703-74-3 |
| Inhibitor Type | Selective FGFR3 Kinase Inhibitor |
| Chemical Formula | C23H22ClFN8O2 |
| Molecular Weight | 496.93 g/mol |
| Purity | ≥98% (subject to batch COA) |
| Storage Conditions | Store at-20°C |
Key Research Applications
Selective FGFR3 Targeting
Investigate FGFR3-mediated signaling pathways and their roles in tumor cell proliferation, survival, and oncogenic signaling.
FGFR3 Mutation Research
Explore the biological activity of FGFR3 alterations, including activating mutations, gene fusions, and gatekeeper resistance mutations.
Targeted Therapy Resistance Studies
Support research into acquired resistance mechanisms and next-generation FGFR3-targeted therapeutic strategies.
Advanced Solid Tumor Research
Provide a research tool for investigating FGFR3-altered advanced solid tumors, particularly urothelial carcinoma and related oncology models.
Secure Packaging｜Controlled Storage｜Safe Delivery
Professional Logistics Team
Dedicated global transport specialists managing secure, compliant, and end-to-end delivery.
International Reach
Seamless shipping services tailored for diverse corporate clients across multiple countries and regions.
Reliability Guarantee
100% safe, efficient, and trackable transit so your operations run without disruption.
Why Source LOXO-435 From Us?
High-Purity Research Material
Purity specification of ≥98%, with batch-specific quality documentation available upon request.
01
Direct Supply & Competitive Pricing
Direct sourcing solutions designed to support pharmaceutical companies, biotechnology startups, and research institutions with competitive procurement costs.
02
Fast Response & Quotation
Our sales team responds promptly to product inquiries, quotation requests, and bulk procurement requirements.
03
COA & Quality Documentation
Request batch-specific Certificates of Analysis (COA) and relevant product documentation to support your procurement and laboratory quality management processes.
04
Flexible Shipping Solutions
Professional packaging and coordinated shipping arrangements to support domestic and international research material deliveries.
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