Product introduction
1-(methylsulfonyl)spiro[dihydroindole-3,4'-piperidine] (CAS No. 178261-41-1) is an important organic intermediate, mainly used in pharmaceutical synthesis and fine chemical industries.
This substance is an advanced spirocyclic heterocyclic building block. The "spiro" design is a crucial scaffold for accurate binding to biological targets in contemporary medicinal chemistry because it offers great molecular stiffness and a particular three-dimensional orientation.
In medicinal chemistry, this spirocyclic molecule is a highly sought-after scaffold, especially in the synthesis of growth hormone secretagogue receptor (GHSR) agonists and CNS-active drugs. With precise analytics, TIANJIN YINAO guarantees the greatest level of structural integrity.
Complete IUPAC Name: 1-methylsulfonyl-1,2-dihydrospiro[indole-3,4'-piperidine]
Molecular Formula: C13H18N2O2SC13H18N2O2S
Exact Mass: 266.1089 Da (Monoisotopic)
CAS Number: 178261-41-1
Purity: ≥≥ 98% (HPLC)
Synthesis Pathway & Key Intermediates
To guarantee that the methylsulfonyl group is only bonded to the indoline nitrogen, our production method places a strong emphasis on regioselectivity. The following essential intermediates are typically involved in the synthesis:
- Intermediate A: The crucial heterocyclic core is spiro [indoline-3,4'-piperidine].
- The 1'-Boc protected core of intermediate B, tert-butyl spiro[indoline-3,4'-piperidine]-1'-carboxylate, ensures regioselective sulfonylation at the N1 position.
- The protected precursor prior to final deprotection is Intermediate C: 1'-Boc-1-(methylsulfonyl)spiro[indoline-3,4'-piperidine].
TIANJIN YINAO attains minimum residual metallic catalysts and improved crystalline stability by managing these intermediary steps.
R&D Client Focus: Custom Synthesis & Scalability
We are aware of the particular needs of CROs and pharmaceutical research labs. We provide customized services to assist your drug discovery pipeline in addition to catalog supply:
- Custom Synthesis: Depending on your particular SAR (Structure-Activity Relationship) needs, we can alter the spiro core or the sulfonyl tail (such as ethylsulfonyl or phenylsulfonyl).
- Salt Form Optimization: For optimal solubility in a variety of assay buffers, it is available as either Free Base or Hydrochloride (HCl) salt.
- In-stock and quick worldwide delivery: safely packaged for the transportation of delicate chemicals.
Function
As a pharmaceutical intermediate: This compound is a key intermediate in the synthesis of MK-677, which is used to study the release mechanism of growth hormone (HGH) and may have potential effects on muscle recovery, fat metabolism and bone health.
Application
1. In the field of pharmaceutical synthesis:
It serves as an amide bond condensing agent, protective agent, and protein cross-linking agent for non-natural amino acids and antibody-drug conjugates.
It is a synthetic intermediate for MK677 (a growth hormone-releasing peptide analog).
2. In the field of fine chemicals:
Used in the research and development and production of pesticide and pharmaceutical intermediates, involving processes such as fluorination and coupling reactions.
3. Other applications:
Used as an impurity reference standard for purity assessment, quality control, and environmental monitoring in drug development.
OEM&ODM
We meet our clients' needs with a flexible product supply, offering a variety of dosage forms, including mixed powders, granules, soft and hard capsules, tablets, and gummies, as well as neutral packaging options. All our products reflect our pursuit of organic, safe, and natural quality.
Delivery & Shipping &Package
International Express-- Fedex/DHL/UPS, air shipping and sea shipping, double-clearance custom.
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Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
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Port |
China main port |
Why Choose Us?
1. More Than 15 Years Botanical Extract Supplier, and around 2000 kinds of products!
2. Focused on the development of plant active ingredients for more than 15 years and has a number of national invention patents.
3. International certification system: ISO9001, ISO22000, IP (non GMO), Jewish, halal, organic and other certification.
4. Professional and experienced r&d team: professors from famous universities and experts with decades of working experience in this industry.
5. Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
FAQ
Q: Can I inspect the products before bulk purchase?
A: Of course. You can purchase trial samples of some products. After you are satisfied with the test and place a bulk order, we will refund your sample fee.
Q: How can I ensure the product meets my requirements?
A: We provide sample services for your evaluation. If you have special needs, we can also find suitable products for you in the local market.
Q: Do you provide samples? What is the policy?
A: Yes, we provide discounted samples for many products. Once you pass the test and place an order, the sample fee will be refunded in the subsequent order.
Q: What if I have special product requirements?
A: Please tell us your detailed requirements, and we will use our local resources to try our best to find products that meet your requirements.
Q: How can I evaluate the product before placing a bulk order?
A: We recommend purchasing samples to verify the quality yourself. Sample prices are more favorable, and sample fees are refunded for bulk orders. Q: I'm unsure if the product is suitable, what should I do?
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