Product Description

SR-17018 (CAS 2134602-32-5) is a novel G-protein biased mu-opioid receptor (MOR) agonist. SR-17018 is a groundbreaking method of analgesia in the field of pain research. SR-17018 specifically prioritizes the G-protein signaling pathway, in contrast to conventional opioids (such as morphine or fentanyl), which activate both the G-protein and β-arrestin pathways.

Test Item	Specification	Typical Results
Appearance	White to off-white crystalline powder	Conforms
Identification (1H-NMR)	Must conform to the structure	Conforms
Identification (LC-MS)	Exact Mass: 400.09 ±± 0.5	400.11
Purity (HPLC)	≥≥ 98.0%	98.45%
Loss on Drying	≤≤ 0.5%	0.25%
Heavy Metals	≤≤ 10 ppm	< 5 ppm

Core Mechanisms (The "Metabolic Master Switch")

SR-17018's "Biased Agonism" mechanism, which provides a distinct safety-to-efficacy profile, is the main area of study interest:

Strong Analgesia: In a number of chronic pain models, it shows comparable or better analgesic potency than morphine.
Decreased Side Effects: SR-17018 shows a markedly lower risk of opioid-induced respiratory depression and constipation, the two most hazardous and restrictive side effects of conventional opioids, by reducing β-arrestin 2 recruitment.
Tolerance Mitigation: Studies show that SR-17018 continues to be effective even after repeated doses, providing a possible remedy for the quick development of tolerance associated with traditional opioids.

Research & Application Fields

Research on Pain Management: Examining novel approaches to managing neuropathic and chronic pain without endangering the respiratory system.
Opioid Use Disorder (OUD) Studies: Investigating substances with less potential for abuse that can take the place of conventional opioids.
Receptor Pharmacology: Charting the divergence between G-protein and β-arrestin signaling in the central nervous system.

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