Product introduction
5-Amino-1-methylquinolinium iodide, widely known as 5-Amino-1MQ iodide or NNMTi, is a synthetic small-molecule nicotinamide N-methyltransferase (NNMT) inhibitor. It typically presents as a brown to reddish-brown solid powder, is soluble in dimethyl sulfoxide (DMSO), and is generally stored at -20°C for long-term stability. It is a quinolinium derivative that acts as a selective substrate-site inhibitor of NNMT, with an IC₅₀ of 1.2 μM.
For laboratory research use only.
Core Functions
- Selective NNMT Inhibition: It binds specifically to the substrate-binding site of NNMT, blocking its activity without interfering with related methyltransferases or enzymes in the NAD⁺ salvage pathway. This prevents the methylation of nicotinamide to 1-methylnicotinamide (1-MNA), preserving nicotinamide for NAD⁺ synthesis.
- Metabolic & NAD⁺ Regulation: By increasing NAD⁺ levels, it enhances mitochondrial function, boosts cellular energy output, and activates sirtuin-1 (SIRT1), which supports longevity and DNA repair. It also improves insulin sensitivity, reduces lipogenesis, and helps regulate lipid metabolism and blood glucose.
- Muscle Regeneration Promotion: It drives concentration-dependent differentiation of C2C12 myoblasts in vitro and enhances muscle stem cell proliferation, fusion, and regenerative capacity in aged or injured animal models, improving muscle fiber size and contractile function.
- Low Off-Target Effects: Preclinical data shows no systemic toxicity in mice at therapeutic doses (up to 60 mg/kg/d), with no significant impact on key blood parameters like glucose, cholesterol, or electrolytes.
Application Areas
- Metabolic Disease Research: Extensively used in preclinical studies of obesity, type 2 diabetes, and insulin resistance. It reduces fat accumulation, improves lipid handling, and normalizes body composition in diet-induced obesity (DIO) models when paired with dietary intervention.
- Muscle Health & Anti-Aging Studies: A key tool for researching sarcopenia and age-related muscle loss, as it restores muscle stem cell activity and enhances post-injury regeneration in aged mice.
- Oncology Research: Investigated for its potential to inhibit metastasis (e.g., ovarian cancer models) by modulating NNMT-driven metabolic reprogramming in tumor microenvironments.
- Pharmaceutical & Biotech R&D: Serves as a lead compound for developing novel NNMT-targeted therapeutics and as a critical probe for validating NNMT as a drug target in metabolic and age-related disorders.
- Longevity & NAD⁺ Metabolism Research: Used to study the links between NNMT, NAD⁺ homeostasis, SIRT1 activation, and lifespan regulation, often in combination with NAD⁺ precursors (e.g., NMN, NR).
HPLC&COA
Method of HPLC Analysis (Reference)
To guarantee crisp peaks and good retention, 5-Amino-1MQ, a quaternary ammonium salt, needs certain chromatographic settings.
| Parameter | Specification |
| Column |
C18 Reverse Phase (e.g., Zorbax SB-C18, 4.6 × 150 mm, 5 μm) |
| Mobile Phase A |
0.1% Trifluoroacetic acid (TFA) in Water |
| Mobile Phase B |
Acetonitrile (ACN) |
| Flow Rate | 1.0 mL/min |
| Detection (λ) |
254 nm (Standard) or 280 nm |
| Gradient |
5% B to 95% B over 15 minutes |
Data on Solubility
Temperature and solvent have a significant impact on 5-Amino-1MQ's solubility. For total disintegration, sonication is frequently necessary.
- DMSO: More than 20 mg/mL, very soluble.
- Water: About 2 mg/mL, poorly to moderately soluble.
- Ethanol: Soluble in small amounts.
COA
| Product name | 5-amino-1-mq | Manufacture date | Feb.27.2026 |
| Batch number | TJ260228 | Analysis date | Feb.28.2026 |
| Batch quantity | 100kg | Expiry date | Feb.28.2028 |
| Items | Specifications | Results | |
| Appearance | Reddish brown solid powder | Complies | |
| Purity(HNMR) | ≥98.0% | Complies | |
| Purity(HPLC) | ≥98.0% | 0.991 | |
| 400 MHz 1H | Consistent | Consistent | |
| MS | 159.2±1.0 | 158.2 | |
| Packing description: | Sealed export grade drum & double of sealed plastic bag | ||
| Storage: | Store in cool & dry place not freeze., keep away from strong light and heat | ||
| Shelf life: | 2 years when properly stored |
OEM&ODM
We offer a variety of dosage forms and neutral packaging, including mixed powders, granules, soft capsules, hard capsules, tablets, gummies, and more, to meet the diverse needs of our customers. Yinao is committed to providing customers with natural, safe, and organic plant extracts.
Certifications
The company consistently adheres to its corporate mission of creating a healthy life, strictly controls product quality, and holds certifications including ISO9001, Halal, and Kosher. It continuously innovates and develops, earning the high-tech enterprise certificate for several consecutive years.
Delivery & Shipping &Package
International Express-- Fedex/DHL/UPS, air shipping and sea shipping, double-clearance custom.
|
Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
|
Port |
China main port |
Why Choose Us?
1. More Than 15 Years Botanical Extract Supplier, and around 2000 kinds of products!
2. Focused on the development of plant active ingredients for more than 15 years and has a number of national invention patents.
3. International certification system: ISO9001, ISO22000, IP (non GMO), Jewish, halal, organic and other certification.
4. Professional and experienced r&d team: professors from famous universities and experts with decades of working experience in this industry.
5. Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
FAQ
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