Product introduction
7,8-Dihydroxyflavone (7,8-DHF) is a selective TrkB receptor agonist that primarily works by mimicking the physiological effects of brain-derived neurotrophic factor (BDNF), exhibiting multiple functions including neuroprotection, cardiovascular regulation, and anti-proliferation.
Purity (HPLC): ≥≥ 98.0%
Catalog No.: YINAO-78DHF-01
Format: Pale yellow to brownish-yellow fine powder.
Pack Sizes: 100mg, 500mg, 1g, 5g (Bulk custom available).
Fast Lead Time: Ships within 24-48 hours via FedEx/DHL global express.
Mechanism of Action: TrkB Agonist & BDNF Mimetic
A small-molecule flavonoid of considerable scientific significance is 7,8-Dihydroxyflavone (7,8-DHF). 7,8-DHF exhibits good blood-brain barrier (BBB) permeability and successfully replicates the biological activities of BDNF, in contrast to the protein known as Brain-Derived Neurotrophic Factor (BDNF), which is unable to penetrate the BBB.
Mechanism: 7,8-DHF directly causes TrkB receptor dimerization and autophosphorylation by acting as a high-affinity agonist for the TrkB (Tropomyosin receptor kinase B) receptor. Important downstream signaling pathways, such as MAPK/ERK and PI3K/Akt, are activated by this process.
Research Applications: It is widely used to investigate synaptic plasticity, neuronal survival, and defense mechanisms against neurodegenerative diseases like Parkinson's disease (PD) and Alzheimer's disease (AD).
Analytical : HPLC Purity & HNMR Analysis
Even minute contaminants can cause unexpected experimental results in neuroscience research. TIANJIN YINAO uses a thorough multi-stage analysis to guarantee each batch's ultra-high purity:
HPLC Purity Analysis: Measures chemical purity to make sure related chemicals are not present.
1H NMR Spectroscopy: Verifies the compound's structural integrity and molecular identity.
Conclusion: The principal component is continuously maintained at 98.0%, and the analytical spectra show distinct, crisp peaks. Our outstanding batch-to-batch consistency ensures that study data is highly reproducible, offering a solid basis for sensitive in vitro and in vivo investigations.
Function
1. Neuroprotective Effects
TrkB Receptor Activation: By activating TrkB receptors, mimicking the effects of BDNF, it protects neurons from Aβ toxicity (e.g., a dose of 5 mg/kg/day prevents synaptic loss in an Alzheimer's disease model).
2. Neurodegenerative Diseases:It has neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), reducing infarct size and improving motor dysfunction.
3. Antidepressant and Learning/Memory Effects: It improves mood disorders and cognitive function through the TrkB signaling pathway.
4. Cardiovascular Regulation
Vasodilation: Dose-dependent vasodilation of the rat thoracic aortic ring, partially dependent on endothelial function (intact endothelial EC50 is 24 µmol/L, endothelial-free is 104 µmol/L).
5. Antioxidant and Anti-inflammatory Effects: It may assist in regulating blood lipids and blood pressure by improving endothelial function. Antiproliferative Effects
6. Induction of Apoptosis: In U937 leukemia cells, it inhibits the G1 phase cell cycle and induces apoptosis. The mechanism involves regulation of Bcl-2 family proteins, activation of caspase-3, and the ERK/JNK signaling pathway.
Improvement of Metabolic Syndrome:
Female-Specific: By regulating the hypothalamic-pituitary-ovarian axis and ERα/BDNF/TrkB signaling crosstalk, it improves metabolic syndrome (such as obesity and insulin resistance) induced by a high-fat diet or stress.
OEM&ODM
We offer a variety of dosage forms and neutral packaging, including mixed powders, granules, soft capsules, hard capsules, tablets, gummies, and more, to meet the diverse needs of our customers. Yinao is committed to providing customers with natural, safe, and organic plant extracts.
Certifications
The company consistently adheres to its corporate mission of creating a healthy life, strictly controls product quality, and holds certifications including ISO9001, Halal, and Kosher. It continuously innovates and develops, earning the high-tech enterprise certificate for several consecutive years.
Delivery & Shipping &Package
International Express-- Fedex/DHL/UPS, air shipping and sea shipping, double-clearance custom.
|
Packaging Details |
10g/Bag,1Kg/bag/25kg/Drum,According to your requirements |
|
Port |
China main port |
Why Choose Us?
1. More Than 15 Years Botanical Extract Supplier, and around 2000 kinds of products!
2. Focused on the development of plant active ingredients for more than 15 years and has a number of national invention patents.
3. International certification system: ISO9001, ISO22000, IP (non GMO), Jewish, halal, organic and other certification.
4. Professional and experienced r&d team: professors from famous universities and experts with decades of working experience in this industry.
5. Provide diversified products: the products have been applied to all major international brands in the fields of drugs, dietary supplements, cosmetics, animal nutrition and functional food.
FAQ
Hot Tags: 7,8-dihydroxyflavone, China 7,8-dihydroxyflavone factory, amino tadalafil, resveratrol, β nicotinamide mononucleotide, spermidine 5, fasoracetam, d glucopyranoside
